Scientific Consulting · Translational Medicine

Giuseppe Astarita

Ph.D. — Biochemistry & Molecular Biology

Translational neuroscience scientist specializing in biomarker strategy, multi-omics, and drug development. Twenty years at the intersection of lipidomics, metabolomics, and clinical science — turning complex biology into decisions that advance therapies.

90+
Peer-Reviewed Publications
13K+
Citations
54
h-index
16
Granted Patents
Lipidomics Metabolomics Proteomics Biomarker Strategy LC-MS/MS Translational Neuroscience Rare Disease Clinical Biomarkers

Twenty years translating biology into decisions

I founded MyMetabolome to bring senior-level scientific expertise directly to the organizations that need it — without the overhead of a large consultancy. My work sits at the intersection of lipid biology, multi-omics mass spectrometry, and translational drug development.

Over two decades I have built omics platforms and biomarker programs from the ground up at Denali Therapeutics and Arkuda Therapeutics, advancing assets through proof-of-concept in Alzheimer's, Parkinson's, lysosomal storage disorders, and neuroinflammation. I have led CRO partnerships, shaped regulatory-facing evidence packages, and worked cross-functionally with clinical, regulatory, and bioinformatics teams.

What sets my work apart is depth in lipid biology — an area of rapidly growing importance across neurodegeneration, metabolic disease, and rare disorders — combined with the strategic and leadership experience to translate that science into portfolio-level decisions.

I also hold an adjunct faculty position at Georgetown University, where I lead NIH- and Alzheimer's Association-funded research and mentor the next generation of translational scientists.

What I Offer

Consulting Services

Senior scientific expertise delivered directly — from early biomarker strategy through clinical execution and beyond.

01

Biomarker Strategy

End-to-end biomarker planning for clinical programs — defining MOA, pharmacodynamic, and patient stratification endpoints. Study design, protocol input, and regulatory-facing evidence packages.

02

Multi-Omics Platform Design

Design and oversight of lipidomics, metabolomics, and proteomics workflows using LC-MS/MS and immunoassay platforms (Olink, SomaLogic). Targeted and untargeted approaches across plasma, CSF, serum, and tissue.

03

Assay Development & Validation

Fit-for-purpose assay development and validation for translational and clinical biomarker readouts. CRO selection, oversight, and quality management to ensure regulatory-ready data.

04

Translational Research Design

Hypothesis generation, experimental strategy, and study design for preclinical-to-clinical translation. Integration of multi-omics datasets with clinical endpoints and disease biology.

05

Scientific Advisory

Strategic scientific input for drug development programs, pipeline decisions, and portfolio planning. Expert review of biomarker plans, regulatory documents, and clinical protocols.

06

Grant & Publication Support

Scientific writing, grant strategy, and publication support for academic and industry partners. Experienced in NIH, foundation, and industry-sponsored research frameworks.

Career

Selected Experience

Two decades spanning academia, CRO, and biopharma — from platform building to senior program leadership.

2022 — 2023
Senior Director, Biomarker Discovery
Arkuda Therapeutics · Watertown, MA
Led biomarker strategy for clinical-stage programs in neuroinflammation and lysosomal biology. Built integrated multi-omics pipelines (LC-MS/MS, Olink, SomaLogic). Managed CRO partnerships and regulatory-ready assay validation programs.
2020 — Present
Principal Consultant
MyMetabolome Consulting · Belmont, MA
Advising biotech and pharma clients on translational biomarker strategy, multi-omics platform design, and clinical study integration across neuroscience, rare disease, and metabolic disorders.
2020 — 2022
Senior Scientific Manager
Metabolon · San Francisco, CA
Delivered global metabolomics, lipidomics, and proteomics solutions for pharma and biotech clients. Scientific leadership in experimental design, platform selection, and biomarker interpretation.
2016 — 2020
Principal Scientist, Head of Omics Mass Spectrometry
Denali Therapeutics · South San Francisco, CA
Built centralized multi-omics MS platform supporting biomarker discovery across Alzheimer's, Parkinson's, and lysosomal storage disorder programs. Multiple assets advanced to proof-of-concept. Co-authored 8 publications and co-invented 4 patents.
2011 — 2016
Principal Scientist & Strategic Manager
Waters Corporation · Milford, MA
Advanced LC-MS technologies for lipidomics and metabolomics. Contributed to instrument development, publications, and intellectual property in translational biomarker applications.
2012 — Present
Adjunct Assistant Professor
Georgetown University · Washington, DC
NIH- and Alzheimer's Association-funded research in lipidomics and omics biosignatures in neurodegenerative disease. Teaching and mentorship in translational mass spectrometry.
Scientific Record

Publications & Patents

90+
Publications
13,000+
Citations
54
h-index
16
Granted Patents
2024
Metabolomics and Lipidomics Strategies in Modern Drug Discovery and Development
Drug Discovery Today · Astarita G., Kelly R., Lasky-Su J.
2023
Granulins Rescue Inflammation, Lysosome Dysfunction, Lipofuscin, and Neuropathology in a Mouse Model of Progranulin Deficiency
Cell Reports · Root J., Mendsaikhan A., Taylor G., ... Astarita G. et al.
2022
Ion Mobility Mass Spectrometry in the Omics Era: Challenges and Opportunities for Metabolomics and Lipidomics
Wiley Analytical Science · Astarita G. et al.
Get In Touch

Work Together

I work with biotech and pharma companies at any stage — from early platform strategy to late-phase clinical biomarker execution. If you're looking for senior scientific expertise in lipidomics, metabolomics, or translational biomarker strategy, I'd welcome a conversation.

Location Belmont, MA · Greater Boston